1	Human Anatomy, First Edition McKinley & O'Loughlin Chapter 4 Lecture Outline: Tissue Level of Organization
2	Tissue Level of Organization Tissues are groups of similar cells and extracellular products that carry out a common function.
3	4 Types of Tissues epithelial tissue connective tissue muscle tissue nervous tissue
4	Epithelial Tissue Lines every body surface and all body cavities. Forms both the external and internal lining of many organs. Constitutes the majority of glands. Composed of one or more layers of closely packed cells that form a barrier between two compartments having different components. Little to no extracellular matrix. No blood vessels penetrate an epithelium.
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6	Characteristics of Epithelial Tissue: Cellularity Composed almost entirely of cells bound closely together by different types of cell junctions.
7	Characteristics of Epithelial Tissue: Polarity Apical surface (free, or top, surface) Intercellular junctions Basal surface (fixed, or bottom, surface)
8	Characteristics of Epithelial Tissue: Attachment The basal surface of an epithelium is bound to a thin basement membrane.
9	Characteristics of Epithelial Tissue: Avascularity Lack blood vessels. Nutrients obtained either directly across the apical surface or by diffusion across the basal surface.
10	Characteristics of Epithelial Tissue: Innervation Some epithelia are richly innervated to detect changes in the environment at that body or organ surface. Most nervous tissue is in the underlying connective tissue.
11	Characteristics of Epithelial Tissue: Regeneration Capacity Frequently damaged or lost by abrasion and is replaced via high regeneration capacity. Continual replacement occurs through the divisions of the deepest epithelial cells (called stem cells) near its base.
12	Functions of Epithelial Tissue Protection Regulation of materials into and out of the organ or tissue Produce secretions Endocrine glands Exocrine glands
13	Functions of Epithelial Tissue Nerve endings detect changes in the external environment at their surface. Continuously supply information to the nervous system concerning touch, pressure, temperature, and pain.
14	Junctions There are four types of cell junctions: tight junctions adhering junctions desmosomes gap junctions
15	Endocrine Glands Lack ducts and secrete their products directly into the interstitial fluid and bloodstream. Hormones act as chemical messengers to influence cell activities elsewhere in the body.
16	Exocrine Glands Usually maintain their contact with the epithelial surface by means of a duct. Duct secretes materials onto the surface of the skin or onto an epithelial surface lining an internal passageway.
17	Classification of Exocrine Glands Form and structure (morphology) simple glands vs. compound glands Type of secretion tubular vs. acinar ducts Method of secretion tubuloacinar gland
18	Secretion Types Serous glands produce and secrete a nonviscous, watery fluid, such as sweat, milk, tears, or digestive juices. Mucus glands secrete mucin, which forms mucus when mixed with water. Mixed glands, such as the two pairs of salivary glands inferior to the oral cavity, contain both serous and mucus cells, and produce a mixture of the two types of secretions.
19	Merocrine Glands Also called eccrine glands, package their secretions in structures called secretory vesicles which travel to the apical surface of the glandular cell and release their secretion by exocytosis. The glandular cells remain intact and are not damaged in any way by producing the secretion.
20	Holocrine Gland Secretion is produced through the destruction of the secretory cell. Lost cells are replaced by cell division at the base of the gland.
21	Apocrine Gland Secretion occurs with the “decapitation” of the apical surface of the cell and the subsequent release of secretory product and some cellular fragments. Examples: the mammary glands and some sweat glands in the axillary and pubic regions
22	Connective Tissue Most diverse, abundant, widely distributed, and microscopically variable of the tissues. Designed to support, protect, and bind organs. Binds body structures together.
23	Basic Components of CT All CT share three basic components: cells protein fibers ground substance
24	Components of CT: Cells connective tissue proper contains fibroblasts, fat contains adipocytes, cartilage contains chondrocytes, and bone contains osteocytes. Many CT’s contain white blood cells such as macrophages, which phagocytize foreign materials.
25	Components of CT: Protein Fibers Most contains protein fibers throughout the tissue. Strengthen and support connective tissue. Type and abundance of these fibers varies depending on function.
26	Components of CT: Protein Fibers Three basic types of protein fibers: collagen fibers are strong and stretch-resistant elastic fibers are flexible and resilient reticular fibers form an interwoven framework
27	Components of CT: Ground Substance Cells and the protein fibers reside within a material called ground substance. Nonliving material produced by the connective tissue cells. Primarily consists of molecules composed of protein and carbohydrate and variable amounts of water. May be viscous (blood), semisolid (cartilage), or solid (bone).
28	Functions of Connective Tissue Physical protection Support and structural framework Binding of structures Storage Transport
29	Development of Connective Tissue The primary germ layer mesoderm forms all connective tissues. There are two types of embryonic connective tissue: mesenchyme mucous connective tissue
30	Classification of Connective Tissue The connective tissue types present after birth are classified into three broad categories: connective tissue proper supporting connective tissue fluid connective tissue
31	The Resident Cells of the Connective Tissue Proper Fibroblasts Adipocytes Fixed macrophages Mesenchymal cells
32	The Wandering Cells of the Connective Tissue Proper Mast cells Plasma cells B-lymphocytes Macrophages Leukocytes
33	2 Broad Categories of CT Loose connective tissue Dense connective tissue based on the relative proportions of cells, fibers, and ground substance
34	Supporting Connective Tissue Cartilage and bone Form a strong, durable framework that protects and supports the soft body tissues. Extracellular matrix contains many protein fibers and a ground substance that ranges from semisolid to solid.
35	Fluid Connective Tissue Blood is a fluid connective tissue composed of cells called formed elements. erythrocytes (red blood cells) leukocytes (white blood cells) platelets erythrocytes transport oxygen and carbon dioxide between the lungs and the body tissues leukocytes mount an immune response platelets are involved with blood clotting
36	Muscle Tissue Responds to stimulation from the nervous system causing them to shorten. Produce voluntary and involuntary movement.
37	Nervous Tissue Sometimes termed neural tissue. Consists of neurons, or nerve cells, and glial cells that support, protect, and provide a framework for neurons.
38	Neurons Detect stimuli, process information quickly, and rapidly transmit electrical impulses from one region of the body to another. Prominent cell body functions in control; information processing, storage, and retrieval; internal communication.
39	Neurons Processes extend from the nerve cell body. Dendrite Axon
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